Sildenafil is a preparation for treatment \prophylaxes of ED and a pulmonary arterial hypertensia. The preparation has been developed in 1998 by pharmaceutical firm Pfizer and now is on sale under a brand names Viagra and Revatio. This preparation operates as an inhibitor fosfodiesterazy-5, enzyme which regulates a circulation in a genital of men. For today competitors of a preparation Viagra are Cialis (Tadalafil)and Levitra Vardenafil)– .
It is a little from history Viagra
Preparation sildenafil – "Viagra" has been synthesised the very first time by pharmacists of company Phizer and Kent, the research centre in England. Initially this preparation was developed for hypertonia treatment (the raised blood pressure) and a stenocardia (an ischemic heart trouble). The first clinical researches of a preparation have been spent in hospital Morriston of the city of Svonsi. The first stage clinical researches within the path of Yana Ostrelo shows that this planning has not made expected effect, but it can cause a penis erection. To It, firm Phizer has decided to sell it as a preparation from impotence problems, instead of from a stenocardia. The preparation has been branded in 1996 since the preparation meant for medication and preventive maintenance of male impotence and has been confirmed on March, 27th, 1998, as the first peroral preparation for treatment of ED. And a year later, a turn of sale Viagra has made 1 billion US dollars.
The system of activity Viagra
The system of actions Viagra consists in liberation oxide nitrogen (NO) immediately within cavernous body of a penis. Oxide nitrogen contacts receptors enzyme sodium guanylate cyclases which leads to increasing of degree of cyclic Mononatrii phosphas of a guanine which stimulates a pleasure of unstriated muscle groups of an penis. Due to the given action blood inflow to a penis is enlarged.
Sildenafil is really a effective and picky inhibitor fosfodiesterazy-5, a hormone that is in charge of destruction of Mononatrii phosphas of a guanine in cavernous little bodies of a penis. Sildenafil is metabolized with enzymes of a liver also it is allocated through a liver and kidneys. At its use with fats, time necessary for achievement of the necessary concentration in a blood is enlarged.
The use to destination
Sex dysfunction
Primary appointment Sildenafil citrate is treatment of male impotence (disability to support an erection at level, the enough for sexual activity end). Viagra it's used for cure for ED in most categories, including diabetes. It's well-known that the people using antidepressants as can be subject to erectile dysfunction. Researches of 2003 show that sildenafil improves sexual function at men in cases like this.
Pulmonary hypertensia
The same as and for cure for erection problems, viagra can use it for treatment of such rare disease, as a pulmonary arterial hypertensia. Sildenafil relaxs walls of arteries leading to depressive disorders of pulmonary arterial prevention and pressure. It, in turn, reduces a load on a heart right ventricle. Sildenafil citrate has been officially accepted to be used in these purposes in the end of 2005.
"High-rise" illness of lungs
Sildenafil has well proved at treatment of the high-rise fluid lungs bound to oxygen starvation at height. For example, at climbers. Though this effect has been found out recently,
Sports
Professional sportsmen often accept Viagra (or other preparations containing active substance sildenafil) for an arteriectasia and veins that positively influences enrichment of a blood and, hence, muscles oxygen. This action helps to raise productivity of an organism in certain cases.
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